By Y. Sancho. Appalachian School of Law. 2018.

Therefore buy antivert 25mg, the residues Arg33 order antivert 25mg overnight delivery, Gln104, Ser201 and Asn224 correspond to Arg274, Gln345, Ser442 and Asn465 in the real sequence. Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, E. Depending on the parasite specie the clinical manifestations vary from localized ulcerative skin lesions to disseminated visceral infection. The latter is the most severe form of the disease, which is fatal when left untreated. However the recommended therapy is far from satisfactory due to the emergence of resistances, severe side effects and the limited efficacy owing to disease exacerbation, mainly associated with compromised immune capability (e. Eugène Bataillon, 34095 Montpellier Cx 5, France; 4 The Robert Gordon University, School of Pharmacy and Life Sciences, St. S Nagar-160062, Punjab, India; Abstract Leishmaniasis is a parasitic disease caused by the protozoan parasites of the genus Leishmania. Depending on the parasite specie the clinical manifestations vary from localized ulcerative skin lesions to disseminated visceral infection. The latter is the most severe form of the disease, which is fatal when left untreated. However the recommended therapy is far from satisfactory due to the emergence of resistances, severe side effects and the limited efficacy owing to disease exacerbation, mainly associated with compromised immune capability (e. Depending on the parasite specie the clinical manifestations vary from localized ulcerative skin lesions to disseminated visceral infection. The latter is the most severe form of the disease, which is fatal when left untreated. A vertebrate host becomes infected with Leishmania, through the bite of an infected sandfly (Phlebotomus and Lutzomya spp) along with its blood meal, by the inoculation of infective flagellated promastigotes that invade or are phagocytosed by local or recruited host cells. In the phagolysosomes, the promastigotes will differentiate into non-flagellated amastigotes that multiply and are able to infect other adjacent or distant macrophages. The disease control is dependent on drug therapy once no approved human vaccine is available. Pentavalent antimonials, represented by sodium stibogluconate and meglumine antimoniate, have been the first-line treatment in many endemic areas for more than 7 decades (Chappuis et al. Among the antimonials severe adverse effects, are the life-threatening acute pancreatitis and cardiac arrhythmia. Amphotericin B has replaced antimonials as first-line treatment in many areas of the Bihar State in India, where treatment unresponsiveness is more than 60% (Sundar et al. Although, it administration requires close medical supervision due to high toxicity (fever with rigor and chills, thrombophlebitis and occasional serious toxicities like myocarditis, severe hypokalaemia, renal dysfunction and even death) (Sundar et al. The toxic events were substantially reduced by the emergence of Amphotericin B lipid formulations (Sundar et al. Indeed, these formulations allowed a targeted drug delivery to parasites, once they are preferentially internalised by the reticuloendothelial cells. Even these formulations are used as first-line treatment in Europe and United States, its use in endemic areas was precluded due to economic reasons (Gradoni et al. It is highly effective (adults and children’s) and well tolerated, with limited side effects that are usually mild and temporary (Sundar et al. However, miltefosine is teratogenic, being its use strictly forbidden in pregnant women’s or in women’s who could become pregnant within two months of treatment (Sindermann et al. Non internalized parasites were removed and serial dilutions of each drug were added. Parasite load quantification The parasite load in the liver and spleen was determined by the limiting dilution method as previously described (Buffet et al. The organs were then submitted in quadruplicate, to the serial 2-fold dilutions in a 96 well microtitration plates. The plates were incubated at 27ºC for 15 days and then each well was inspected for the presence or absence of promastigotes. The final titter was the last dilution for which, at least one 5 promastigote was recorded. The number of parasites per gram of organ (parasite load) was calculated as follows: parasite load= [(geometric mean of reciprocal titter from each quadruplicate cell culture/weight of homogenized organ) x reciprocal fraction of the homogenized organ inoculated into the first well]. Blood analysis Uncoagulated blood samples were used to obtain a complete blood evaluation, including total red blood cell, haemoglobin, hematocrit, total white blood cells, and granulocyte, monocyte, lymphocyte counts. The inhibition of the parasites growth induced by each drug were evaluated by measuring the activity of the reporter protein, luciferase. Indeed, this assay was previously validated to be used in drug screening experiments (Roy et al.

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Reducton of metabolic drug eliminaton is more pronounced in malnourished or frail subjects generic antivert 25mg with amex. The water content of the aging body decreases order antivert 25mg with amex, the fat content rises, hence the distributon volume of hydrophilic compounds is reduced in the elderly, whereas that of lipophilic drugs is increased. Aside of these pharmacokinetc changes, one of the characteristcs of old age is a progressive decline in counterregulatory (homeostatc) mechanisms. Therefore drug efects are mitgated less, the reactons are usually stronger than in younger subjects, the rate and intensity of adverse efects are higher. Examples of drug efects augmented in this manner are, postural hypotension with agents that lower blood pressure, dehydraton, hypovolemia, and electrolyte disturbances in response to diuretcs, bleeding complicatons with oral antcoagulants, hypoglycemia with antdiabetcs, and gastrointestnal irritaton with non-steroidal ant-infammatory drugs. Psychotropic drugs but also antconvulsants and centrally actng anthypertensives may impede intellectual functons and motor coordinaton. The antmuscarinic efects of some antdepressants and neuroleptc drugs may be responsible for agitaton, confusion, and delirium in elderly. If drug therapy is absolutely necessary, the dosage should be ttrated to a clearly defned clinical or biochemical therapeutc goal startng from a low inital dose. Storage The term used to describe the safe keeping of all fnished drugs and pharmaceutcals awaitng dispatch. The term is also applied for safe stores in hospitals and dispensaries under the specifed conditons, so as to maintain their quality and potency. Dosage Form Refers to the gross physical form in which a drug is adminis- tered to or used by a patent. Drug Product A dosage form containing one or more actve therapeutc ingredients along with other substance included during manu- facturing process. Finished Product A medicinal product which has completed all stages of manu- facture including packaging. Strength The concentraton of the drug substance (for example weight/ weight, weight/volume or unit dose/volume basis) and the potency i. Stability Degree of resistance to chemical and physical changes, the efcacy of the preparaton must remain constant or change only within the limit specifed by ofcial compendia. Expiraton Date The date placed on the immediate container label of a drug product that designates the date through which the product is expected to remain within specifcatons. Storage Procedure and Instructons Drugs must be stored under conditons which minimize dete- rioraton, contaminaton or damage. They must be stored under conditons compatble with their recommended storage requirements of temperature and humidity and where neces- sary to comply with legal requirements, under secured or segregated conditons. Appropriate storage conditons are: Temperature or humidity controlled environment must be equipped with suitable indicators, recorders and/or failure warning devices which must be checked at appropriate inter- vals and the results are coded. Temperature should be measured at diferent levels in the warehouse and if necessary storage of sensitve drugs should be restricted to locatons in the warehouse where they will be protected from extreme conditons. Temperatures of the refrigerators, deep freezers, and Relatve Humidity in humidity control area as well as general areas of storage at room temperature should be recorded on a daily basis. Storage conditons not related to temperature are indicated in following terms: Drug storage should be regularly checked for cleanliness and good order and for misplaced/deteriorated/out dated stock. Drugs with expired shelf life should be destroyed unless an extension of shelf life is granted following the sats- factory results or re-analysis. Some categories of supplies require special storage condi- tons which include vaccines, narcotcs, and combustbles e. Narcotcs and other controlled substances should be kept in secure locking rooms with only one entrance. Inspecton for Deterioraton Pharmacists should be aware that deterioraton of drug product may happen even before their expiraton. Hence inspecton should include frequent product examinaton to detect signs of product deterioraton which difer according to dosage form. The Pharmacists in the Stores should prepare an exhaustve list of following deterioraton/spoilage indicators and keep them. Liquid Dosage Forms Slight gradual discolouraton, Swirly precipitaton, Whickering: pin hole at ampoule tp that leaks soluton which precipitate or crystalline solid mater, clouding, fading of colour, Cake sedimentaton (suspension), Creaming and cracking (emul- sion), Discolouraton. Semisolid Dosage Forms Ointments creams, gels and suppositories -Change in consist- ency and feel to touch, Phase separaton, Discolouraton, Surface crystal growth 3. Solid Dosage Forms Surface chipping or pitng (plain tablets), Deformaton (capsules), Increased hardness, Discolouraton, Colour fading (coloured tablets), Chipping of coat (coated tablets). Most vitamins, hormones enzymes are highly sensitve to oxidaton and photo decompositon. The integrity of packaging of dosage form is one of the impor- tant tasks of inspecton for pharmacist as these protect the drug in a tailored fashion.

This method was designed to be complementary to the recent structure-based virtual screening studies generic antivert 25 mg with mastercard, although it was exclusively based on ligand information only generic 25 mg antivert with visa. This so-called frequent substructure 150 Substructure-based Virtual Screening mining, i. Several screening models were constructed by varying the parameters of substructure generation and score calculation. These models were benchmarked and the best performing model was subsequently applied for large-scale screening on a commercial vendor library. The first set consisted of 892 low-affinity antagonists, with activity values between 5. For analysis of the antagonists, each antagonist set was compared against a background set of 10,000 drug-like molecules. Each pair of antagonist and background sets represented an individual training set from which a model was created. To analyze the structural features of the molecules, the molecular structures were first converted into a machine readable format, i. In addition to normal chemical representation, translation into one of three elaborate chemical representations was also explored as alternative representations when converting the source molecules to graphs. The translated source and background compounds were then subjected to frequent substructure mining. Frequent substructure mining is a data mining technique that finds all frequently occurring substructures that are present in a preset 151 Chapter 5 26,27 minimum number of molecules, which in this study was set to 30% of the size of the set; a substructure is defined as any part of the molecule, ranging from a single atom to the complete structure. The number of generated substructures for each source set and chemical representation are provided in Table 1. In general, smaller sets, such as the high-affinity antagonists set (255 molecules) result in significantly higher numbers of generated substructures compared to larger sets, such as the low-affinity (892 molecules) and combined antagonist (1,147 molecules) sets. With increasing set size, the chance for an individual substructure to occur more frequently than the set minimum decreases, resulting in finding fewer substructures. In addition, the high mutual similarity between antagonists in the high-affinity set results in more substructures with frequencies above the support threshold. Number of generated substructures for each source set and chemical representation. Activity Range [a] Representation pKi ≥ 8 pKi ≥ 5 5 ≤ pKi < 8 Normal 4,424 471 408 Ar. Examples of discriminative substructures for high-affinity adenosine A2A antagonists versus drug-like background compounds. Note that the provided examples are all within the set of the 50 top ranking substructures. A2A Background Score Nr Substructure antagonists compounds contribution a N N 242 (94. Note that the provided examples are all within the set of the 50 top ranking substructures (described below). All substructures in Table 2 are also present in compound 1 (note that substructures may overlap). For two of these substructures, c and d of Table 2, this is illustrated in Figure 2. This figure shows one example of how substructures are positioned in the molecules they originate from. Note that the methanediamine substructure, c, occurs three times in compound 1 (and also once in compound 3 and twice in compound 2, Figure 1). For frequency calculations, however, it was counted 153 Chapter 5 only once per molecule. Substructures c and d each represent one of two types of substructures that exist: substructures that are clear molecular fragments such as rings and functional groups (d) and substructures that have an unspecified shape (c). The structure of compound 1 with two examples of discriminative substructures for A2A antagonists highlighted in bold. For each frequent substructure in the antagonist set, the occurrence in the background set was also determined. For instance, substructure c in Table 2 occurred in 247 of the 255 A2A antagonists, or 96. Since these substructures are frequently occurring in the A2A antagonists and infrequently in background compounds they are signified as ‘discriminative’ for A2A antagonists. This discriminative property is quantified by calculating the difference between the fraction of antagonists and the fraction of background compounds in which the substructures occur. This difference is referred to as ‘score contribution’ of a substructure and is used to rank the substructures. The top-ranked substructures, those with the highest score contribution, are the most ‘discriminative’ ones and were subsequently used for the screening. This is because the frequency of a in the background set is considerably lower than that of b, resulting in a higher score contribution for a.

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How- verse reactions to pacli- ever order antivert 25mg line, the Japanese women in this study were Putting it into a plan taxel: less likely than the American patients (6% ver- These results are important to consider when • bone marrow suppres- sus 29 cheap antivert 25 mg without prescription. Docetaxel Adverse reactions to do- Quick quiz cetaxel include: • hypersensitivity reac- tions 1. What’s the major adverse reaction that’s common to all alky- • fluid retention lating drugs? Bone marrow suppression is a common adverse re- • numbness and tingling action to all alkylating drugs. The drug likely to be administered with methotrexate to mini- mize its adverse effects is: A. Leucovorin is typically administered in conjunction with methotrexate to minimize adverse effects. Before administering bleomycin to a patient, why should you administer an antihistamine and an antipyretic? An antihistamine and an antipyretic may be adminis- tered before bleomycin to prevent fever and chills. For cases of smallpox, institute airborne precautions for the duration of the illness and until all scabs fall off. For pneumonic plague cases, institute droplet precautions for 72 hours after initiation of effective therapy. In the event of chemical agent exposure, follow standard precautions and decontamination protocols, such as removing cloth- ing and sealing it in plastic bags, irrigating the eyes, washing skin and hair using copious water, treating waste water as needed, and decontaminating the health care facility according to the specific agent involved. Chemical agent Treatment Antidote Chemical agent Treatment Antidote Nerve agents • Supportive • Atropine I. Phosgene intubation and zures Sulfur dioxide mechanical ventilation with Cyanides • Supportive • Amyl nitrite via positive-end Cyanogen chloride care inhalation expiratory Hydrogen cyanide • 100% oxygen • Sodium nitrite pressure by face mask; I. Herbal medicine Common uses Special considerations Aloe Oral • The laxative actions of aloe may take up to 10 hours after ingestion to • Constipation be effective. Ginseng • Fatigue • Ginseng may cause severe adverse reactions when taken in large • Improve concentration doses (more than 3 g per day for 2 years), such as increased motor and • Treat atherosclerosis cognitive activity with significant diarrhea, nervousness, insomnia, hy- • Also believed to strengthen pertension, edema, and skin eruptions. John’s wort • Mild to moderate depression • Effects may take several weeks; however, if no improvement occurs • Anxiety after 4 to 6 weeks, consider alternative therapy. John’s wort shouldn’t be used in combination with prescription • Viral infections antidepressants or antianxiety medications. Therapies for Glaucoma,” Expert Opinion on Emerg- ing Drugs 10(1):109-18 February 2005. Philadel- cine in an Outpatient Oncology Center,” Clinical phia: Lippincott Williams & Wilkins, 2007. Introductory Clinical Pharma- out Parathyroid Glands,” Endocrinology 146(2):544- cology, 8th ed. Clinical Geriatric Psychopharmacology, 4th physiologic Basis of Drug Therapy, 2nd ed. Adrenergic blocking drugs, 40-47 Aminophylline, 183-185 Anticholinergic drugs, 27-32, 60-62, topical, 416t Amiodarone, 131-132 177-178 Adrenergic drugs, 32-39 Amitriptyline, 322-325 Anticholinesterase drugs, 24-27 classifying, 32 Amlodipine, 138-140 differentiating toxic response to, mechanism of action of, 33i Ammonium chloride, 368-369 from myasthenic crisis, 24 Adsorbent drugs, 204-205 Amobarbital, 316-317 mechanism of action of, 22i Adverse drug reactions, 17-19 Amoxapine, 322-325 Anticoagulant drugs, 161-171 dose-related, 17-18 Amoxicillin, 196-197, 241-243 Anticonvulsant drugs, 68-85 patient sensitivity–related, 18-19 Amphetamine salts, mixed, 336-337 Antidepressants, 320-329 Agonist, 12 Amphotericin B, 280-283, 418t risks of, 322 Albuterol, 37-39, 176-177 Ampicillin, 241-243 Antidiabetic drugs, 339-345 Alclometasone, 419t Amprenavir, 272-275 Antidiarrheal drugs, 208-210 Aldesleukin, 408-409 Amylase, 206 Antidiuretic hormone, 350-352 Aldosterone, 301 Amyl nitrite, 135-136 Antiemetics, 216-219 Alemtuzumab, 398-399 Anakinra, 302-306 Antiestrogens, 388-390 Alfuzosin, 40-43 Anastrozole, 387-388 Antiflatulent drugs, 205 Alkalinizing drugs, 366-368 Androgens, 390-391 Antifungal drugs, 280-289 Alkylating drugs, 371-379 Anesthetic drugs, 108-115 dermatologic, 418t mechanism of action of, 373i ophthalmic, 414t Antigout drugs, 306-309 otic, 417t Antihistamines, 216-219, 294-297 i refers to an illustration; t refers to a table. Carboplatin, 378-379 Atazanavir, 272-275 Biperiden, 60-62 Carboxamides, 80-81 Atenolol, 43-47, 137-138 Bisacodyl, 214-215 Carboxylic acid derivatives, 76-78 Atorvastatin, 149-150 Bisoprolol, 43-47 Cardiac glycosides, 120-122 Atracurium, 56-58 Bistriazole antimycotic drug, 285-287 Cardiovascular drugs, 119-152 Atropine, 27-32, 30i, 416t Bitolterol, 37-39 Carisoprodol, 50-52 Atypical antipsychotics, 331-332 Bivalirudin, 169-170 Carmustine, 375-376 Autonomic nervous system drugs, Bleomycin, 385-386 Carteolol, 43-47, 416t 21-47 Boric acid, 417t Carvedilol, 43-47, 141-142 Azaspirodecanedione derivatives, 319 Bortezomib, 400-402 Caspofungin, 287-288 Azatadine, 294-295, 297 Brimonidine, 416t Castor oil, 214-215 Azathioprine, 302-306 Brinzolamide, 416t Catecholamines, 33-37 i refers to an illustration; t refers to a table. See also inhibitors, 66-68 mechanism of action of, 22i Nonsteroidal anti-inflammatory Cefaclor, 243-246 Choline salicylate, 94-96 drugs. See Dactinomycin, 385-386 Centrally acting skeletal muscle relax- also Calcium channel blockers. Dalteparin, 161-164 ants, 50-52 Clemastine, 294-295, 297 Dantrolene, 52-53 Central nerve block, 113i Clindamycin, 248-249, 418t, 420t Darbepoetin alfa, 160-161 Cephalexin, 243-246 Clioquinol, 281 Darifenacin, 230-231 Cephalosporins, 243-246 Clobetasol, 419t Darunavir, 272-275 mechanism of action of, 245i Clocortolone, 419t Daunorubicin, 385-386 Cerumenolytics, 417t Clomipramine, 322-325 Decongestants, 191-193 Cetirizine, 294-295, 297 Clonazepam, 74-76, 312-313, 314i, 315 Delavirdine, 270-271 Cevimeline, 21-24 Clonidine, 141-142 Demecarium, 24-27 Chamomile, 423t Clopidogrel, 165-169 Demeclocycline, 247-248 Chemical weapons exposure, treat- Clorazepate, 74-76, 312-313, 314i, 315 Depolarizing blocking drugs, 58-59 ment and antidotes for, 422t Clotrimazole, 281, 418t Dermatologic drugs, 418-420t Chloral hydrate, 317-318 Clove oil, 114-115 Desflurane, 109-110 Chlorambucil, 372-374 Clozapine, 331-332 Desipramine, 322-325 Chloramphenicol, 417t, 421t Cocaine, 112-115 Desloratadine, 294-295, 297 Chlordiazepoxide, 312-313, 314i, 315 Codeine, 102-105, 188-189 Desmopressin, 350-352 Chloroprocaine, 112-114 Colchicine, 307-309 Desonide, 419t Chlorothiazide, 224-225 Colesevelam, 147-148 Desoximetasone, 419t Chlorpheniramine, 294-295, 296i, 297 Colestipol, 147-148 Dexamethasone, 298-300, 415t, Chlorpromazine, 216-219, 333-336 Colistin sulfate, 417t 417t, 419t Chlorpropamide, 342-345 Competitive drugs, 56-58 Dexchlorpheniramine, 294-295, 297 Chlorthalidone, 224-225 Competitive inhibition, 107 Dextroamphetamine, 336-337 Chlorzoxazone, 50-52 Corticosteroids, 178-180, 297-301 Dextromethorphan, 188-189 Cholesterol absorption inhibitors, 152 special population concerns Diazepam, 53-55, 74-76, 312-313, 314i, Cholestyramine, 147-148 and, 179 315, 422t Choline magnesium trisalicylate, 94-96 Corticotropin, 349-350 Diazoxide, 142-143 Cholinergic agonists, 21-24 Corticotropin repository, 349-350 Dibucaine, 114-115 mechanism of action of, 22i Cortisone, 298-300 Diclofenac, 98-100, 415t Cholinergic blocking drugs, 27-32, Cosyntropin, 349-350 Dicloxacillin, 241-243 60-62, 177-178 Co-trimoxazole, 257-259 Dicyclomine, 27-32 i refers to an illustration; t refers to a table. Pirbuterol, 37-39, 176-177 Psyllium hydrophilic mucilloid, 212-213 Paromomycin, 238-240 Piroxicam, 98-100 Purine analogues, 383-384 Paroxetine, 320-322 Pituitary drugs, 348-352 Pyrazinamide, 276-280 Partial agonists, 44 Plants as drug sources, 3 Pyridostigmine, 24-27 Passive transport, 7 Podophyllotoxins, 396-397 Pyrimidine analogues, 381-383 Pathogen resistance, preventing, Polycarbophil, 212-213 mechanism of action of, 382 237-238 Polyenes, 280-283 Pyrophosphate analogues, 264 Patient sensitivity–related reactions, Polyethylene glycol, 211-212 Pyrrolidines, 84-85 18-19 Polymyxin B sulfate, 417t Patient’s response to drug, factors that Polythiazide, 224-225 Q affect, 15 Polyvinyl alcohol, 415t Quazepam, 312-313, 314i, 315 Peak concentration, 11-12 Positive inotropic effect, 119-120 Quetiapine, 331-332 Pediculicides, 420t Posterior pituitary drugs, 350-352 Quinapril, 144-145 Pegaspargase, 404 Potassium replacement, 360-361 Quinidine, 124-125 Penbutolol, 43-47 Potassium-sparing diuretics, 227-228 Penciclovir, 418t R Potentiation, 16 Penicillin-binding proteins, 241-242 Rabeprazole, 201-202 Pramipexole, 62-66 Penicillins, 241-243, 421t Radioactive iodine, 355-356 Pramoxine, 114-115 Pentazocine, 105-107 Ramelton, 317-318 Pravastatin, 149-150 Pentobarbital, 316-317 Ramipril, 144-145 Prazosin, 40-43, 141-142 Pentostatin, 383-384 Ranitidine, 199, 200i, 201 Prednisolone, 178-180, 298-300, 415t Peptic ulcer drugs, 195-203 Rasagiline, 62-66 Prednisone, 178-180, 298-300 Peripheral vascular resistance, 136 Recombinant human activated protein Prilocaine, 112-114 Permethrin, 420t C, 289-290 Primidone, 70-72 Perphenazine, 216-219, 333-336 Rectal route of administration, 5 Probenecid, 306-307 Pharmacodynamics, 12-13, 14i Remifentanil, 102-105 Procainamide, 124-125 Pharmacokinetics, 7-12 Repaglinide, 342-345 Procaine, 112-114 Pharmacologic class, 2 Replacement therapy, 15 Procarbazine, 405 Pharmacotherapeutics, 14-15 Reserpine, 141-142 Prochlorperazine, 216-219 Phenazopyridine hydrochloride, Respiratory drugs, 175-193 Procyclidine, 60-62 100-101 Respiratory route of administration, 5 Prodrug, 10 Progestins, 392-393 i refers to an illustration; t refers to a table. Yohimbine, 424t Triptorelin, 393-395 Tromethamine, 366-368 Z Tropicamide, 416t Zafirlukast, 180-182 Trospium, 230-231 Zaleplon, 317-318 Tuberculosis Zidovudine, 266-270, 268i directly observable therapy for, 276 Zileuton, 180-182 drug regimens for treating, 276-280 Ziprasidone, 331-332 Typical antipsychotics, 333-336 Zolmitriptan, 86-88 i refers to an illustration; t refers to a table. Professor and Executive Dean, South Carolina College of Pharmacy, The University of South Carolina, Columbia, Medical University of South Carolina, Charleston, South Carolina William J. Professor and Dean, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Jane M. The information presented herein reflects the opinions of the contributors and reviewers. Drug information and its applications are constantly evolving because of ongoing research and clinical experience and are often subject to professional judgment and interpretation by the practitioner and to the uniqueness of a clinical situation. However, the reader is advised that the publisher, author, contributors, editors, and reviewers cannot be responsible for the continued currency or accuracy of the information, for any errors or omissions, and/or for any consequences arising from the use of the information in the clinical setting. Acquisition Editor: Hal Pollard Managing/Development Editor: Dana Battaglia Production: Silverchair Science + Communications, Inc. Library of Congress Cataloging-in-Publication Data Concepts in clinical pharmacokinetics / Joseph T. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without written permission from the American Society of Health-System Pharmacists.

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